Breaking Through My Life in Science by Katalin Karikó

Breaking Through My Life in Science by Katalin Karikó | 15.11 MB
English | N/A Pages

Title: Breaking Through: My Life in Science
Author: Katalin Karikó
Year: 2023

A powerful memoir from Katalin Karikó, winner of the 2023 Nobel Prize in Physiology or Medicine, whose decades-long research led to the COVID-19 vaccines
“Katalin Karikó’s story is an inspiration.”-Bill Gates
“Riveting . . . a true story of a brilliant biochemist who never gave up or gave in.”-Bonnie Garmus, author of Lessons in Chemistry
Katalin Karikó has had an unlikely journey. The daughter of a butcher in postwar communist Hungary, Karikó grew up in an adobe home that lacked running water, and her family grew their own vegetables. She saw the wonders of nature all around her and was determined to become a scientist. That determination eventually brought her to the United States, where she arrived as a postdoctoral fellow in 1985 with $1,200 sewn into her toddler’s teddy bear and a dream to remake medicine.
Karikó worked in obscurity, battled cockroaches in a windowless lab, and faced outright derision and even deportation threats from her bosses and colleagues. She balked as prestigious research institutions increasingly conflated science and money. Despite setbacks, she never wavered in her belief that an ephemeral and underappreciated molecule called messenger RNA could change the world. Karikó believed that someday mRNA would transform ordinary cells into tiny factories capable of producing their own medicines on demand. She sacrificed nearly everything for this dream, but the obstacles she faced only motivated her, and eventually she succeeded.
Karikó’s three-decade-long investigation into mRNA would lead to a staggering achievement: vaccines that protected millions of people from the most dire consequences of COVID-19. These vaccines are just the beginning of mRNA’s potential. Today, the medical community eagerly awaits more mRNA vaccines-for the flu, HIV, and other emerging infectious diseases.

Breaking Through isn’t just the story of an extraordinary woman. It’s an indictment of closed-minded thinking and a testament to one woman’s commitment to laboring intensely in obscurity-knowing she might never be recognized in a culture that is driven by prestige, power, and privilege-because she believed her work would save lives.

“A riveting testament to resilience and the power of unwavering belief, Breaking Through charts an inspirational journey from growing up in postwar communist Hungary to transforming the world with mRNA.” -Jennifer Doudna, Nobel Prize laureate in chemistry and author of A Crack in Creation
“Katalin Karikó’s story is an inspiration. Anyone who has ever doubted that science, innovation, and persistence can change the world should read this book.” -Bill Gates, #1 New York Times bestselling author of How to Avoid a Climate Disaster
“Karikó’s proven recipe (from the creative Hungarian kitchen) for a breakthrough in science: Start with an insatiable curiosity in education and research. Then, for a few decades, look for gaps in knowledge; work hard for years to fill some of them; don’t give up because of difficulties or circumstances; and, finally, seize the opportunity to help solve one painful problem of humanity, thereby opening new horizons for the future of medicine. Bon appétit, enjoy your sweets!” -Ernő Rubik, inventor of the Rubik’s Cube and author of Cubed
“Katalin Karikó’s remarkable life story, which incidentally began not far from where I spent my childhood, inspires us not to be held back even in the face of severe difficulties. It encourages us to stay strong and follow through with important ideas that can change the world.” -Stefan Hell, Nobel Prize laureate in chemistry
“Inspiring, riveting. . . . An outstanding memoir with a happy ending.” Kirkus Reviews (starred review)
“Karikó describes her research with a palpable sense of wonder, . . . successfully distilling complex scientific matters. The result is the rousing story of a remarkable woman and her lifesaving contributions to medicine.” Publishers Weekly

About the Author
Katalin Karikó, PhD, is a Hungarian American biochemist who specializes in RNA-mediated mechanisms. She is an adjunct professor of neurosurgery at the University of Pennsylvania, and her research was foundational in the development of the Pfizer-BioNTech and Moderna mRNA vaccines.

Excerpt. © Reprinted by permission. All rights reserved.
A Butcher’s Daughter
There is a story my family likes to tell: a moment I cannot remember. I am a toddler, still chubby-cheeked, with a blunt blond bob. I am standing in the yard of my childhood home. In front of me, my father has begun butchering the family pig. This is his work, his vocation. He is a butcher. It’s how he earns his livelihood, and it’s how he keeps us alive. He’s been doing this work professionally since he was twelve years old.
The dead animal lies on its back atop a platform of bricks, which keep it from getting muddy. My father singes the fur with a handheld wood burner, similar to a blowtorch. He slices open the long belly of the animal, reaches into the cavity. He scoops out innards, working carefully so as not to puncture the organs. Lumpy intestines glisten. Then he lifts a hatchet and hacks the animal into two equal halves at the spine. Now what lies in front of me seems less like an animal, a being, and more like a product. At last, he begins dividing the carcass into bright red cuts of muscle.
This scene is too much for my sister, Zsuzsanna, three years older than me. Zsoka, as I call her, is not squeamish. This is postwar Hungary, after all. Squeamishness is a luxury afforded to no one-let alone a hand-to-mouth laboring family like ours. But whatever it is that has captivated me in this moment does not seem to have the same effect on my sister.
Still, I am captivated.
My parents used to chuckle, remembering the way I looked then: my wide eyes taking everything in-the whole complex topography of an animal’s interior. All those disparate parts that for so long worked together to keep this one creature alive. All the mystery and wonder they seemed to hold, visible at last.
This, for me, is how it begins.
While I cannot remember those early moments seeing my father work, I recall, precisely, the world that surrounded them, the landscape of my childhood.
Kisujszallas: central Hungary, the northern great plain region. Clay soils. Sweeping grasslands. A medium-size agricultural town of roughly ten thousand people. We aren’t as isolated as some towns; we’re a stop on the railroad, for one thing. Also, Route 4, a primary route to Budapest, goes through town. There are a few paved streets, though my family’s road is made from packed dirt.
Our home is simple, small. It is constructed, literally, from the earth that surrounds it: clay and straw, pressed into adobe walls, whitewashed, then covered with a thick roof of reeds. The reeds, as I remember, have faded in the sun. They look like a shaggy gray wig.
We live in a single room. The house is larger than this one room, but for most of the year, the other rooms are too cold for anything but storage. We live where the heat is.
In a corner of the room is the source of that warmth: a sawdust stove, the cheapest possible way to generate heat. It’s constructed from sheet metal, about a half meter across, like an ordinary metal barrel with a central cylinder that is packed with sawdust. We collect that sawdust from a nearby wooden toy factory, carrying it home from the factory with the help of horses. Once home, we store the sawdust in the barn, in a pile taller than my father. In the summer we check the pile regularly to make sure it hasn’t started generating its own heat; sawdust is known to spontaneously combust.
The sawdust stove grows hot enough that my mother sometimes uses it as an extra cooktop. When it really gets going, the exterior metal glows red. Zsoka and I long ago learned to keep our distance, lest we burn our skin. It’s our job, though, to fill the insert container with sawdust every morning. This is hard work, and it must be done carefully. Like many of the things we do, it isn’t a chore-at least not in the sense that people use the word now. It’s not something that our parents ask us to do, not a favor we’re doing for the family. It’s simply what must be done. If we don’t do it, our family will freeze.
At the center of the room is a large table. Here we prepare and eat meals, sometimes gathering extended family for boisterous celebrations. At this table, my sister and I do homework and read, help our mother roll out fresh pasta from flour and eggs.
Each night, my father stands at the head of the table, doling out dinner servings to each of us. He served in the army during World War II and cooked for hundreds of soldiers on the front line, rationing foods with precision. I can still see him today: He ladles pasta into his own soup bowl. “Soldiers during the war on the front lines!” he hollers. Then he reaches for my mother’s bowl. “Soldiers during the war in the back country!” Then he reaches for my bowl, then my sister’s, giving us kids the smallest servings. “Soldiers during peacetime,” he says quietly.
Then he laughs and serves us all a little more. Times might be hard now, but he’s known worse. Every adult has.
Nearby are the beds where we sleep: mine and Zsoka’s, our mother and father’s. The beds are so close, we can reach out to touch one another during the night.
Outside is not only my father’s smokehouse (where sausages hang, dripping thick globs of fat, stained orange from the paprika, onto the floors) but also the barn, where, already, a new pig is growing. Next year’s meat. In the yard, chickens peck the earth, and we have several gardens. In the main garden, we grow food for our family: carrots, beans, potatoes, and peas. Dinner is made from whatever happens to be ready for harvest (flavored, like the sausages, with paprika-always lots of paprika). Zsoka and I have a garden of our own, too. Every spring, we place seeds in the ground. Our fingers are still clumsy, but we are gentle as we work. Gently we cover these seeds with soil, then-weeks later-watch shoots push their way into open air and stretch toward the sun. We also grow fruit. We have apple, quince, and cherry trees, plus a grape arbor and pergolas.
And there are flowers, too: blue hyacinths, white daffodils and violets, and great bursts of roses, which together make this humble homestead feel a bit like Eden.
Someday, decades in the future and an ocean away from here, in a land I haven’t yet heard of called Philadelphia, I’ll settle down in a home on a wide suburban street. There I’ll go in search of flowers to plant, and it is only when I struggle to find white daffodils that I will understand what I’m doing: searching not just for any blooms, but for these, the flowers I knew as a little girl, the ones I can remember my mother planting and tending.
Outside of town lie fields of corn. We plant this corn ourselves, using hoes to soften the soil and cut the weeds. We thin the plants, pull weeds from the soil, fertilize the ground with cow manure, and then harvest the crops. We give the kernels to the animals, then use the cobs to fuel the kitchen stove.
Everything is like that: Nothing goes to waste. We shake walnuts from trees, eat the nuts, and burn the leftover shells as fuel.
It will be years before plastic becomes a part of my life, years before I understand the concept of garbage, the idea that some things are so useless they can simply be thrown away.
We don’t have a cow, but our neighbor does. Every morning, my sister or I run over to the neighbor’s home with an empty jug. We fill the jug with milk still warm from the udder and serve it for breakfast. Leftovers become kefir. When we rinse the last milk from glasses, we pour the cloudy water into a pot for the pig, who devours everything greedily.
As we scurry around, getting ready for the day (the indoor air so cold our breath is sometimes visible), we listen to a small radio. Each morning, an announcer tells us whose “name day” it is. Every day of the year, a different name, a different person in our lives to celebrate: February 19, Zsuzsanna; November 19, Erzsebet. Good morning, the voice on the radio might say. It’s October 2, which means it’s the name day for Petra. The name comes from a Greek word that means stone, or rock. . . . Then, when we arrive at school, we know whose name day it is, and we wish them a happy one. It’s a good system. How many of us really know the birthdays of the people in our lives? But if you know someone’s name, then you know their name day, and can wish them well.


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